周欣，冰球突破客座教授，中国科学院精密测量科学与技术创新研究院研究员，博导，院长。基金委创新研究群体项目负责人，国家杰出科学青年基金、国家重大科研仪器设备研制专项（部委推荐）和国家重点研发计划首席科学家。现任国家自然科学基金委员会医学科学部第六届专家咨询委员会委员，国际华人医学磁共振学会主席，中国化学会理事，中国生物物理学会分子影像学专委会副主任委员。获2023年度国家技术发明奖二等奖（第一完成人）、湖北省科技奖一等奖（2次）、全国创新争先奖、首届科学冰球突破探索奖、CCTV 2018年度全国十大科技创新人物、“王天眷波谱学奖”等荣誉。
主要从事医学影像与生物医学工程的新仪器、新技术及新应用研究，在我国率先开展多核（多种原子核）磁共振成像（MRI）临床研究。自主研制的创新冰球突破器械--人体肺部多核磁共振成像装备获国家药品监督管理局批准上市，是当前全球首台获批的可用于气体成像的临床多核磁共振成像装备。成功“点亮”肺部，解决传统MRI对肺部空腔无法清晰成像的难题，在全国多家三甲医院开展了慢阻肺、肿瘤、新冠肺炎等肺部重大疾病的临床应用。发展了多核和人工智能的MRI新技术，为肺部和脑部等重大疾病和肿瘤的早期检测提供新的医学影像手段与策略。发表SCI论文180余篇，授权国内外发明专利110余件。
招生需求：
招收物理、化学、生物医学工程及相关专业的硕士生和博士生2-3人，博士后2人。
联系方式：xinzhou@wipm.ac.cn
荣誉与奖励：
2023 国家技术发明奖二等奖
2023 朱良漪分析仪器创新成果奖
2021 中国科学院年度创新人物
2020 全国创新争先奖
2019 首届科学冰球突破探索奖
2019 “国家高层次人才特殊支持计划”科技创新人才
2018 CCTV 2018年度全国十大科技创新人物
2016 中国科学院青年科学家奖
代表性论著：
1 Haidong Li#, Xiuchao Zhao#, Yujin Wang#, Xin Lou#, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S. Bouchard, Liming Xia*, Xin Zhou*. Damaged Lung Gas Exchange Function of Discharged COVID-19 Patients Detected by Hyperpolarized 129Xe MRI. Science Advances, Vol 7(1), eabc8180. (2021).
2 Yuan Fang#, Haidong Li#, Luyang Shen, Ming Zhang, Ming Luo, Hongchuang Li, Qiuchen Rao, Qi Chen, Yecheng Li, Zimeng Li, Xiuchao Zhao, Lei Shi, Qian Zhou, Yeqing Han, Fumin Guo, Xin Zhou*. Rapid Pulmonary 129Xe Ventilation MRI of Discharged COVID-19 Patients with Zigzag Sampling. Magnetic Resonance in Medicine, Vol 92(3), 956-966. (2024).
3 Zimeng Li#, Sa Xiao#, Cheng Wang, Haidong Li, Xiuchao Zhao, Caohui Duan, Qian Zhou, Qiuchen Rao, Yuan Fang, Junshuai Xie, Lei Shi, Fumin Guo, Chaohui Ye, Xin Zhou*. Encoding Enhanced Complex CNN for Accurate and Highly Accelerated MRI. IEEE Transactions on Medical Imaging, Vol 43(5), 1828-1840. (2024).
4 Lei Zhang#, Maosong Qiu#, Ruifang Wang, Sha Li, Xiaoxun Liu, Qiuyi Xu, Long Xiao, Zhongxing Jiang, Xin Zhou*, Shizhen Chen*. Monitoring ROS Responsive Fe3O4-based Nanoparticle Mediated Ferroptosis&Immunotherapy via 129Xe MRI. Angewandte Chemie International Edition, e202403771. (2024).
5 Yuqi Yang#, Baolong Wang#, Xu Zhang, Hongchuang Li, Sen Yue, Yifan Zhang, Yunhuang Yang, Maili Liu, Chaohui Ye, Peng Huang*, Xin Zhou*. Activatable Graphene Quantum-Dot-Based Nanotransformers for Long-Period Tumor Imaging and Repeated Photodynamic Therapy. Advanced Materials, Vol 35(23), 2211337. (2023).
6 Qiao Yu#, Lei Zhang#, Mou Jiang, Long Xiao, Yunhui Xiang, Ruifang Wang, Zhaoqing Liu, Rui Zhou, Minghui Yang, Conggang Li, Maili Liu, Xin Zhou, Shizhen Chen*. An NIR Fluorescence Turn-on and MRI Bimodal Probe for Concurrent Real-time in Vivo Sensing and Labeling of β-Galactosidase. Angewandte Chemie International Edition, Vol 62(46), e202313137. (2023).
7 Shizhen Chen#, Long Xiao#, Yu Li, Maosong Qiu, Yaping Yuan, Rui Zhou, Conggang Li, Lei Zhang, Zhongxing Jiang, Maili Liu, Xin Zhou*. In Vivo Nitroreductase Imaging via Fluorescence and Chemical Shift Dependent 19F NMR. Angewandte Chemie International Edition, Vol 61(50), e202213495.(2022).
8 Cheng Wang#, Lu Huang#, Sa Xiao#, Zimeng Li, Chaohui Ye, Liming Xia*, Xin Zhou*. Early Prediction of Lung Lesion Progression in COVID-19 Patients with Extended CT Ventilation Imaging. European Journal of Nuclear Medicine and Molecular Imaging, Vol 48, 4339-4349. (2021).
9 Qingbin Zeng#, Binglin Bie#, Qianni Guo*, Yaping Yuan, Qi Han, Xiaocang Han, Mingwei Chen, Xu Zhang, Yunhuang Yang, Maili Liu, Pan Liu, Hexiang Deng*, Xin Zhou*. Hyperpolarized Xe NMR Signal Advancement by Metal-Organic Framework Entrapment in Aqueous Solution. PNAS, Vol 117(30), 17558-17563. (2020).
10 Ming Zhang#, Haidong Li#, Yi Xiao#, Hongchuang Li, Xiaoling Liu, Xiuchao Zhao, Yu Zheng, Yeqing Han, Fumin Guo, Xianping Sun, Jianping Zhao, Shiyuan Liu*, Xin Zhou*. Assessment of Global and Regional Lung Compliance in Pulmonary Fibrosis With Hyperpolarized Gas MRI. Journal of Magnetic Resonance Imaging. (2024). DOI: 10.1002/jmri.29497.
11 Qiuchen Rao#, Haidong Li#, Qian Zhou#, Ming Zhang, Xiuchao Zhao, Lei Shi, Junshuai Xie, Li Fan, Yeqing Han, Fumin Guo, Shiyuan Liu, Xin Zhou*. Assessment of Pulmonary Physiological Changes Caused by Aging, Cigarette Smoking, and COPD with Hyperpolarized 129Xe Magnetic Resonance. European Radiology. (2024). DOI: 10.1007/s00330-024-10800-w.
12 Ming Zhang#, Haidong Li#, Hongchuang Li, Xiuchao Zhao, Xiaoling Liu, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Dynamic Evaluation of Acute Lung Injury Using Hyperpolarized 129Xe Magnetic Resonance. NMR in Biomedicine, Vol 37(4), e5078. (2024).
13 Zimeng Li#, Sa Xiao#, Cheng Wang, Haidong Li, Xiuchao Zhao, Qian Zhou, Qiuchen Rao, Yuan Fang, Junshuai Xie, Lei Shi, Chaohui Ye, Xin Zhou*. Complementation-Reinforced Network for Integrated Reconstruction and Segmentation of Pulmonary Gas MRI with High Acceleration. Medical Physics, Vol 51(1), 378-393. (2024).
14 Shizhen Chen#, Lei Zhang#, Sha Li, Yaping Yuan, Bin Jiang, Zhongxing Jiang, Xu Zhang, Xin Zhou*, Maili Liu*. Detecting Biomarkers by Dynamic Nuclear Polarization Enhanced Magnetic Resonance. National Science Review. (2024). DOI: 10.1093/nsr/nwae228.
15 Long Xiao#, Lei Zhang#, Sha Li, Yue Zhu, Qiao Yu, Zhaoqing Liu, Maosong Qiu, Yu Li, Shizhen Chen*, Xin Zhou*. Visualization and Quantification of Drug Release by GSH-Responsive Multimodal Integrated Micelles. JACS Au, Vol 4(3), 1194-1206. (2024).
16 Chenlu Yuan#, Qianni Guo*#, Qingbin Zeng, Yaping Yuan, Weiping Jiang, Yuqi Yang, Louis-S. Bouchard, Chaohui Ye, Xin Zhou*. Dual-Signal Chemical Exchange Saturation Transfer (Dusi-CEST): An Efficient Strategy for Visualizing Drug Delivery Monitoring in Living Cells. Analytical Chemistry, Vol 96(4), 1436-1443. (2024).
17 Xu Zhang#, Yuqi Yang#, Yaping Yuan, Sen Yue, Xiuchao Zhao, Quer Yue, Qingbin Zeng, Qianni Guo, Xin Zhou*. Hyperpolarized 129Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging. Analytical Chemistry. (2024).
18 Qian Zhou#, Haidong Li#, Qiuchen Rao#, Ming Zhang, Xiuchao Zhao, Luyang Shen, Yuan Fang, Hongchuang Li, Xiaoling Liu, Sa Xiao, Lei Shi, Yeqing Han, Chaohui Ye, Xin Zhou*. Assessment of Pulmonary Morphometry using Hyperpolarized 129Xe Diffusion-Weighted MRI with Variable-Sampling-Ratio Compressed Sensing Patterns. Medical Physics, Vol 50(2), 867-878. (2023).
19 Ruifang Wang#, Maosong Qiu#, Lei Zhang#, Meiju Sui, Long Xiao, Qiao Yu, Chaohui Ye, Shizhen Chen*, Xin Zhou*. Augmenting Immunotherapy via Bioinspired MOF-based Ros Homeostasis Disruptor with Nanozyme-Cascade Reaction. Advanced Materials, Vol 35(49), 2306748. (2023).
20 Haiwei Shan, Lei Shi, Shuang Liu, Yaping Yuan, Hongchuang Li, Shizhen Chen, Xin Zhou*. A Local-Saturation-and-Delay MRI Method for Evaluation of Red Blood Cells Aggregation in Vivo for Tumor-Bearing or Drug-Used Rats. Frontiers in Bioengineering and Biotechnology, Vol 11, 1111840. (2023).
21 Cheng Wang#, Haidong Li#, Sa Xiao, Zimeng Li, Xiuchao Zhao, Junshuai Xie, Chaohui Ye, Liming Xia, Xin Lou, Xin Zhou*. Abnormal Dynamic Ventilation Function of COVID-19 Survivors Detected by Pulmonary Free-Breathing Proton MRI. European Radiology, Vol 32, 5297-5307 (2022).
22 Shizhen Chen#, Maosong Qiu#, Ruifang Wang, Lei Zhang, Conggang Li, Chaohui Ye, Xin Zhou*. Photoactivated Nanohybrid for Dual-Nuclei MR/US/PA Multimodal-Guided Photothermal Therapy. Bioconjugate Chemistry, Vol 33(9), 1729-1740. (2022).
23 Qian Zhou#, Qiuchen Rao#, Haidong Li, Ming Zhang, Xiuchao Zhao, Lei Shi, Chaohui Ye, Xin Zhou*. Evaluation of Injuries Caused by Coronavirus Disease 2019 Using Multi-Nuclei Magnetic Resonance Imaging. Magnetic Resonance Letters, Vol 1(1), 2-10. (2021).
24 Weiping Jiang#, Qianni Guo#, Qing Luo, Xiaoxiao Zhang, Yaping Yuan, Haidong Li, Xin Zhou*. Molecular Concentration Determination Using Long-Interval Chemical Exchange Inversion Transfer (CEIT) NMR Spectroscopy. The Journal of Physical Chemistry Letters, Vol 12, 8652-8657. (2021).
25 Yuqi Yang, Yingfeng Zhang, Baolong Wang, Qianni Guo, Yaping Yuan, Weiping Jiang, Lei Shi, Minghui Yang, Shizhen Chen, Xin Lou, Xin Zhou*. Coloring Ultrasensitive MRI with Tunable Metal-Organic Frameworks. Chemical Science, Vol 12(12), 4300-4308. (2021).
26 Ming Zhang#, Haidong Li#, Hongchuang Li, Xiuchao Zhao, Qian Zhou, Qiuchen Rao, Yeqing Han, Yina Lan, He Deng, Xianping Sun, Xin Lou, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Lung Injury Caused by PM2.5 Using Hyperpolarized Gas Magnetic Resonance. Magnetic Resonance in Medicine, Vol 84, 569-578. (2020).
27 Sa Xiao#, He Deng#, Caohui Duan, Junshuai Xie, Haidong Li, Xianping Sun, Chaohui Ye, Xin Zhou*. Highly and Adaptively Undersampling Pattern for Pulmonary Hyperpolarized 129Xe Dynamic MRI. IEEE Transactions on Medical Imaging, Vol 38(5), 1240-1250. (2019).
28 Yuqi Yang#, Shizhen Chen#, Haidong Li, Yaping Yuan, Zhiying Zhang, Junshuai Xie, Dennis.W Hwang, Aidong Zhang, Maili Liu, Xin Zhou*. Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging. Nano Letters, Vol 19(1), 441-448. (2019).
29 Haidong Li#, Zhiying Zhang#, Jianping Zhong, Weiwei Ruan, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou*. Oxygen-Dependent Hyperpolarized 129Xe Brain MR. NMR in Biomedicine, Vol 29(3), 220-225. (2016).
30 Haidong Li, Zhiying Zhang, Xiuchao Zhao, Xianping Sun, Chaohui Ye, Xin Zhou*. Quantitative Evaluation of Radiation-Induced Lung Injury with Hyperpolarized Xenon Magnetic Resonance. Magnetic Resonance in Medicine, Vol 76(2), 408-416. (2016).
31 李海东#，陈世桢#，娄昕，张定宇，周欣*. 多核磁共振成像助力新冠肺炎疫情防控. 中国科学基金，Vol 36(4), 644-653. (2022).
32 叶朝辉*，骆清铭*，周欣*. 影像揭示生命奥秘. 中国科学：生命科学，Vol 50(11), 1155-1157. (2020).
专利：
1. Xin Zhou; Yeqing Han; Xianping Sun; Lei Shi; Maili Liu; Chaohui Ye; Device Having Inert Gas Nucleus Channel and Method for Magnetic Resonance Imaging Using the Same, 2022-10-19, 欧洲, EP3422036B1.
2. Xin Zhou; Xianping Sun; Xiuchao Zhao; Maili Liu; Chaohui Ye; Optical-Fiber Atomic Light-Filtering Apparatus, 2020-10-6, 美国, US10795171B2.
3. 周欣；袁亚平；郭茜旎；孙献平；叶朝辉；使用绝热射频脉冲测量射频B1场分布的磁共振成像方法，2020-8-11，中国，ZL201911151143.1。
4. 周欣；谢军帅；石磊；孙献平；叶朝辉；一种基于降升频的磁共振成像方法，2019-10-25，中国，ZL201810906189.9。
5. 周欣；肖洒；邓鹤；孙献平；叶朝辉；一种基于变采样率的肺部超极化气体动态成像方法，2018-12-25，中国，ZL201610743164.2。
主持科研项目：
1、 国家自然科学基金委员会，国家重大科研仪器研制项目（自由申请），82127802，脑部多核超灵敏MRI仪器研制，2022-01至2026-12，839万元，在研，主持
2、 国家自然科学基金委员会，创新研究群体项目，21921004，生命波谱与成像，2020-01至2024-12，1050万元，在研，主持
3、 科学技术部，国家重点研发计划，2018YFA0704000，肺癌的超高灵敏谱学与成像新技术研究，2019-01至2024-08，2740万元，在研，主持
4、 国家自然科学基金委员会，国家杰出青年科学基金，81625011，超灵敏磁共振成像，2017-01至2021-12，350万元，已结题，主持
5、 国家自然科学基金委员会，国家重大科研仪器设备研制专项（部委推荐），81227902，用于人体肺部重大疾病研究的磁共振成像仪器系统研制，2013-01至2017-12，4400万元，已结题，
